abstract：:In the last years some important therapies were introduced in the treatment of rheumatoid arthritis (RA), which represent a significant clinical advance. This concerns the introduction of TNF blockade with etanercept and inflixmab, the combination of DMARDs, leflunomide and the COX-2-specific inhibitors. In the year 2...

journal_title：Zeitschrift fur Rheumatologie

authors： Edelmann E

更新日期：2001-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is mainly characterized by synovial hyperplasia, pathological immune phenomena and progressive destruction of the affected joints. Various cell types are involved in the pathogenesis of RA including T cells, antigen presenting cells, and endothelial ce...

journal_title：Zeitschrift fur Rheumatologie

authors： Seemayer CA,Distler O,Kuchen S,Müller-Ladner U,Michel BA,Neidhart M,Gay RE,Gay S

更新日期：2001-10-01 00:00:00

abstract：:Ocular manifestations of systemic vasculitides are extraordinarily pleomorph and have been described for many decades. In the introduction the special interaction of the immune system and the eye is outlined. Thereafter diagnostic procedures of patients suffering from systemic vasculitides are shown from an ophthalmol...

journal_title：Zeitschrift fur Rheumatologie

authors： Nölle B

更新日期：2001-08-01 00:00:00

abstract：INTRODUCTION:Methotrexate (MTX) is an antineoplastic agent widely used in low dose to treat patients with rheumatoid arthritis (RA). Its side effects can partly be explained by folate antagonism. Folinic acid (Leucovorin) is generally administered with MTX to decrease MTX-induced toxicity. However information regarding...

journal_title：Zeitschrift fur Rheumatologie

authors： Shahin AA,Ismail MM,Saleh AM,Moustafa HA,Aboul-Ella AA,Gabr HM

更新日期：2001-04-01 00:00:00

abstract：:Autoreactivity plays a major role in the pathogenesis of RA. The rheumatoid factor has been and still is for now more than 50 years the only autoreactivity that is clinically applied in the diagnosis of RA. This well reflects the current way of thinking that a single antigen or a single cause drives an individual into...

journal_title：Zeitschrift fur Rheumatologie

authors： Bläss S,Engel JM,Burmester GR

更新日期：2001-02-01 00:00:00

abstract：:Insufficiency fractures are fractures in bones with nontumorous disease (e.g., osteoporosis, rheumatoid arthritis or following radiation) at normal load. Two cases of insufficiency fracture of the ilium and sacrum are presented. Predisposing factors, clinical picture, imaging procedure and therapy are outlined. ...

journal_title：Zeitschrift fur Rheumatologie

authors： König A

更新日期：2000-10-01 00:00:00

abstract：:Intra-articular injection of corticosteroids is a powerful anti-inflammatory treatment with relatively few side effects. To date no prospective RCT exists on its use in children with oligoarthritis type I. Thus, in January 2000 the Arbeitsgemeinschaft started a multicenter RCT to compare in children with this diagnosi...

journal_title：Zeitschrift fur Rheumatologie

authors： Forster J

更新日期：2000-04-01 00:00:00

abstract：UNLABELLED:The regulatory region of the corticotropin releasing hormone (CRH) is highly conserved and plays a crucial role in the response of the organism to stress. Release of CRH initiates a cascade of events leading to the release of cortisone and the regulation of inflammatory and immune events. OBJECTIVE:Since it...

journal_title：Zeitschrift fur Rheumatologie

authors： Baerwald CG,Mok CC,Tickly M,Lau CS,Wordsworth BP,Ollier B,Panayi GS,Lanchbury JS

更新日期：2000-02-01 00:00:00

abstract：:Inflammation-mediated osteopenia is an animal model for bone mass reduction following chronic inflammation. We found a reduction of calcitriol serum concentrations during the inflammatory process, in addition cytokines are increased. Treatment of the animals with calcitriol is able to prevent bone mass reduction and t...

journal_title：Zeitschrift fur Rheumatologie

authors： Scharla SH,Lempert UG,Kamilli I

更新日期：2000-01-01 00:00:00

abstract：:A dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis. This defect of neuroendocrine regulatory mechanisms contributes to the onset of the model disease. Since these first observati...

journal_title：Zeitschrift fur Rheumatologie

authors： Straub RH,Schölmerich J,Zietz B

更新日期：2000-01-01 00:00:00

abstract：:Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the production of cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, a...

journal_title：Zeitschrift fur Rheumatologie

authors： Besedovsky HO,del Rey A

更新日期：2000-01-01 00:00:00

abstract：:We investigated the relationships between prolactin (PRL) levels and antibody occurrence in systemic lupus erythematosus (SLE). No significant association between PRL levels and the majority of the autoantibodies studied (anti-U1 RNP, anti-rRNP, anti-Sm, anti-dsDNA, anti-DNP, auto-LCA, anti-EACA) could be confirmed (P...

journal_title：Zeitschrift fur Rheumatologie

authors： Kozáková D,Rovenský J,Cebecauer L,Bosák V,Jahnová E,Vigas M

更新日期：2000-01-01 00:00:00

abstract：:Heavy physical work load is a known determinant of osteoarthritis of the hip, which may account for the high risk observed among farmers. On the other hand, the data on influence of heavy manual work in the pathogenesis of hand osteoarthritis are still controversial. We examined 25 retired farm laborers who strenuousl...

journal_title：Zeitschrift fur Rheumatologie

authors： Schmid L,Dreier D,Muff B,Allgayer B,Schlumpf U

更新日期：1999-12-01 00:00:00

abstract：:In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclid...

journal_title：Zeitschrift fur Rheumatologie

authors： Klett R,Puille M,Matter HP,Steiner D,Stürz H,Bauer R

更新日期：1999-08-01 00:00:00

abstract：:Cartilage destruction in arthritis and osteoarthritis is linked to aberrant cytokine and growth factor expression in the affected tissues. It becomes clear that the balance of protective and destructive cytokines is more important for the net destruction than the absolute levels of destructive mediators. IL-1 is a key...

journal_title：Zeitschrift fur Rheumatologie

authors： van den Berg WB

更新日期：1999-06-01 00:00:00

abstract：:Heberden nodes affect mainly middle-aged women. Inheritance is autosomal dominant in female and autosomal recessive in male patients. We report the case of a young man who presented already with 12 years of age with pain in the distal finger joints. There were no other clinical or serological signs for other rheumatoi...

journal_title：Zeitschrift fur Rheumatologie

authors： Rascu A,Kraetsch HG,Grünke M,Kalden JR,Manger B

更新日期：1999-04-01 00:00:00

abstract：:In recent years German authorities established a global budget for health care expenditures solely based on macroeconomic aspects. In the last year there have been attempts to define differentiated budgets for chronic diseases. These plans are mainly defined by quality aspects on the process level (creating networks) ...

journal_title：Zeitschrift fur Rheumatologie

authors： Karger T

更新日期：1998-12-01 00:00:00

abstract：:Health policy in Germany has in recent years given priority to the self-administration of physicians, sickness funds, and hospital associations. Hence, legal regulations on quality assurance have focused on defining responsibilities and areas of primary importance, while precise processes are being defined by the self...

journal_title：Zeitschrift fur Rheumatologie

authors： Luithlen E,Aufderheide E

更新日期：1998-10-01 00:00:00

abstract：AIM:The present study should elucidate the efficacy, patient acceptability, and side effect profiles of Oxaprozin and Diclofenac retard when given to patients with active primary osteoarthrosis. METHODS:80 outpatients with active primary osteoarthrosis with a radiological grade of II or III in the hip or knee joint (m...

journal_title：Zeitschrift fur Rheumatologie

authors： Karbowski A,Schwitalle M,Eckardt A

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Leukotrienes and prostaglandines are important mediators of inflammation. While prostaglandine synthesis can be influenced by NSAIDs therapeutical approaches to the 5-lipoxygenase pathway are rare. Resinous extracts of Boswellia serrata (H15, indish incense), known from traditional ayurvedic medicine, decrea...

journal_title：Zeitschrift fur Rheumatologie

authors： Sander O,Herborn G,Rau R

更新日期：1998-02-01 00:00:00

abstract：:In fibromyalgia as well as in low back pain we frequently find disturbances of the posture of vertebral column clinically and radiologically. Also, reduction in the mobility of whole spine and localized movement impairments in both conditions was present. It is likely that the disturbances are responsible for the firs...

journal_title：Zeitschrift fur Rheumatologie

authors： Müller W,Kelemen J,Stratz T

更新日期：1998-01-01 00:00:00

abstract：:To study the hormonal perturbations in FMS patients we injected sixteen FMS patients and seventeen controls a cocktail of the hypothalamic releasing hormones: Corticotropin-releasing hormone (CRH), Thyrotropin-releasing hormone (TRH), Growth hormone-releasing hormone (GHRH), and Luteinizing hormone-releasing hormone (...

journal_title：Zeitschrift fur Rheumatologie

authors： Riedel W,Layka H,Neeck G

更新日期：1998-01-01 00:00:00

abstract：:Osteoarthritis is the most common joint disease. In addition to known risk factors e.g. genetics, age and hormonal status it has been suggested that chronic-repetitive micro- and substantial (macro-) injury may play an important pathogenetic role. In a longitudinal case-study we examined Judo-players for clinical and ...

journal_title：Zeitschrift fur Rheumatologie

authors： Strasser P,Hauser M,Häuselmann HJ,Michel BA,Frei A,Stucki G

更新日期：1997-12-01 00:00:00

abstract：:Assessment of disease consequences (outcome) requires reliable, valid, and sensitive instruments. Psychometrically sound generic health-status instruments such as the SF-36 have been validated for many languages and are available in German. Instead, most disease specific instruments have been developed in English and ...

journal_title：Zeitschrift fur Rheumatologie

authors： Stucki G,Stucki S,Sangha O

更新日期：1997-10-01 00:00:00

abstract：:This study documents prospectively the Knee Society knee- and function score of 28 patients with rheumatoid arthritis with 34 PFC unconstrained total knee arthroplasties from preoperative values on at yearly intervals. The average follow-up period was 3.4 years (range 2-5.5 y). At last follow-up over 80% of the knees ...

journal_title：Zeitschrift fur Rheumatologie

authors： König A,Janssen E,Scheidler M,Gohlke F

更新日期：1997-07-01 00:00:00

abstract：:Antibodies to double-stranded DNA (anti-dsDNA, dsDNA-Ab) are frequently found in systemic lupus erythematosus (SLE), especially during active disease and differ with respect to immunoglobulin class and avidity. The detection of anti-dsDNA is one of the diagnostic criteria for SLE according to the American College of R...

journal_title：Zeitschrift fur Rheumatologie

authors： Wigand R,Gottschalk R,Falkenbach A,Matthias T,Kaltwasser JP,Hoelzer D

更新日期：1997-03-01 00:00:00

abstract：:The effect of meloxicam, a new non-steroidal anti-inflammatory drug, on spontaneous osteoarthrosis of the ankle joint in Crl: CDBR rats was investigated. The drug was administered in the feed at doses of 0.4, 0.6 and 0.8 mg/kg/day over a period of 2 years to 50 males and 50 females per dose. 100 male rats and 100 fema...

journal_title：Zeitschrift fur Rheumatologie

authors： Mohr W,Lehmann H,Engelhardt G

更新日期：1997-01-01 00:00:00

abstract：UNLABELLED:We report on a 6-year-old Romanian girl with recently diagnosed hyper-IgD-syndrome. The leading symptom of this rare disease are periodic pyrexia, joint involvements (arthralgias/arthritis) and swollen lymph nodes. A permanent increase of alpha 1-acid glycoprotein fucosylation indicates persisting inflammati...

journal_title：Zeitschrift fur Rheumatologie

authors： Suschke J,Walther JU

更新日期：1997-01-01 00:00:00

abstract：:Three new findings are reviewed that help to understand the mechanisms of action of anti-rheumatic gold drugs, such as disodium aurothiomalate (Na2Au(I)TM): i) We found that Na2Au(I)TM selectively inhibits T-cell receptor-mediated antigen recognition by murine CD4+ T-cell hybridomas specific for antigenic peptides con...

journal_title：Zeitschrift fur Rheumatologie

authors： Griem P,Gleichmann E

更新日期：1996-09-01 00:00:00

abstract：:The Lequesne algofunctional indices for the knee and the hip require a physician interview. We adapted the Lequesne indices for the German language and tested the metric properties, test-retest reliability and validity of a self-report questionnaire-format in 51 patients with hip or knee OA. The symptom and function c...

journal_title：Zeitschrift fur Rheumatologie

authors： Stucki G,Meier D,Stucki S,Michel BA,Tyndall AG,Elke R,Theiler R

更新日期：1996-01-01 00:00:00

abstract：:From the about 400 virus species known to cause illness in man, only a small but growing list of representatives are able to induce arthritis. Although virus-associated arthritides are mostly of acute and short-living type, some patients develop long-lasting or even chronic joint inflammation. The viral or host factor...

journal_title：Zeitschrift fur Rheumatologie

authors： Saal JG

更新日期：1995-11-01 00:00:00

abstract：:Light and electron microscopic investigations of joint cartilage in 13 cases of septic arthritis revealed sites of cartilaginous matrix infiltrated with polymorphonuclear granulocytes. This finding confirms rather unknown morphological works done by investigators on this diseases in the late 19th and beginning of the ...

journal_title：Zeitschrift fur Rheumatologie

authors： Gauger M,Mohr W

更新日期：1995-07-01 00:00:00

abstract：:Twenty-three patients with rheumatoid arthritis and relevant anemia (hemoglobin < 11 g/dl) received recombinant erythropoietin (epo) in a therapy study; 90% were responders. A positive correlation of the total epo dose and the amelioration of parameters of red cell line and a negative correlation of the effect of epo ...

journal_title：Zeitschrift fur Rheumatologie

authors： Rave O,Wienands K

更新日期：1995-01-01 00:00:00

abstract：:A case is reported in which a patient with a rheumatoid factor-negative rheumatoid arthritis developed rheumatoid nodules in the penis during treatment with methotrexate. The development of rheumatoid nodules in seronegative rheumatoid arthritis patients is extremely rare. An acceleration of rheumatoid nodules in meth...

journal_title：Zeitschrift fur Rheumatologie

authors： Essig KM,Mayet WJ,Mottrie AM,Helmreich-Becker I,Meyer zum Büschenfelde KH

更新日期：1994-09-01 00:00:00

abstract：:Our aim is to present a new method to examine spinal mobility and spine shape excluding torsional scoliosis. In comparison to measuring devices of the spine used so far, this noninvasive and easy to use method documents altered patterns of intervertebral mobility of the lumbar and thoracic spine. This may lead to a br...

journal_title：Zeitschrift fur Rheumatologie

authors： Hauns B,Ovenhausen K,Hase P,Lorenzen W,Mennet P,Stratz T,Müller W

更新日期：1994-05-01 00:00:00

abstract：:Blastocysts hominis, a protozoon considered to be a nonpathogen intestinal commensal, is now discussed to be a cause of intestinal infection under certain circumstances, e.g., immunosuppression. There are two published cases of Blastocysts infection complicated by arthritis which was classified as "reactive" in one ca...

journal_title：Zeitschrift fur Rheumatologie

authors： Krüger K,Kamilli I,Schattenkirchner M

更新日期：1994-03-01 00:00:00

abstract：:Superficial heat and cold are commonly used therapeutic methods in patients with rheumatoid arthritis. Both procedures have analgesic effect. In 30 inpatients with rheumatoid arthritis the pain threshold was measured before and after warm bath and ice massage. Rheumatoid patients had significantly lower pain threshold...

journal_title：Zeitschrift fur Rheumatologie

authors： Curković B,Vitulić V,Babić-Naglić D,Dürrigl T

更新日期：1993-09-01 00:00:00

abstract：:The author describes the information gained from anamnesis which points to a psychogenetic cause of rheumatic complaints. These symptoms are part of the diagnostically important criteria which must be supplemented still further by means of a personal discussion with the patient. A great deal depends on the skill of th...

journal_title：Zeitschrift fur Rheumatologie

authors： Mathies H

更新日期：1993-07-01 00:00:00

abstract：:After clinical and radiological examination, the elbows of 74 patients with rheumatoid arthritis were examined by ultrasound. Clinical examination gives a good impression of the inflammatory changes of the elbow joint. Sonography was very useful in detecting synovitis and joint effusion and their distribution in the d...

journal_title：Zeitschrift fur Rheumatologie

authors： Sell S,König S,Zacher J

更新日期：1993-05-01 00:00:00

abstract：:Drug treatment in the polymorbid elderly should focus on the more important symptoms. Pharmacokinetic differences should be considered, e.g. a reduced volume of distribution and decreased liver and renal function. Special alterations in the pharmacodynamics with respect to the central nervous system and other organs a...

journal_title：Zeitschrift fur Rheumatologie

authors： Breithaupt H

更新日期：1992-11-01 00:00:00